Elucidating the glycan-binding specificity and structure of Cucumis melo agglutinin, a new R-type lectin

• Jon Lundstrøm,
• Emilie Gillon,
• Valérie Chazalet,
• Nicole Kerekes,
• Antonio Di Maio,
• Ten Feizi,
• Yan Liu,
• Annabelle Varrot and
• Daniel Bojar

Beilstein J. Org. Chem. 2024, 20, 306–320, doi:10.3762/bjoc.20.31

• affinity of CMA1-Nter to GalNAc in solution by isothermal calorimetry (ITC), obtaining a KD of 940 µM, confirming the low affinity (Figure S2c,d; Supporting Information File 2). Structural insights from the N-terminal domain of CMA1 Given the unusual binding specificity exhibited by CMA1, we were intrigued

One-pot synthesis of block-copolyrotaxanes through controlled rotaxa-polymerization

• Jessica Hilschmann,
• Gerhard Wenz and
• Gergely Kali

Beilstein J. Org. Chem. 2017, 13, 1310–1315, doi:10.3762/bjoc.13.127

• description see Supporting Information File 1). The eventual content of free RAMEB in the product was checked by isothermal calorimetry (ITC) and was around 3 wt %. The conversion of the monomers was calculated from the yield of polyrotaxane minus the total RAMEB content. In both cases, the monomer

Discrete multiporphyrin pseudorotaxane assemblies from di- and tetravalent porphyrin building blocks

• Mirko Lohse,
• Larissa K. S. von Krbek,
• Sebastian Radunz,
• Suresh Moorthy,
• Christoph A. Schalley and
• Stefan Hecht

Beilstein J. Org. Chem. 2015, 11, 748–762, doi:10.3762/bjoc.11.85

• dealing with the daunting task to quantify the binding constants for the di- and tetravalent multiporphyrin complexes for example using isothermal calorimetry (ITC), in order to analyze the thermodynamics and kinetics of multivalent binding in these architectures in detail. In the future, we will continue

Synthesis and solvodynamic diameter measurements of closely related mannodendrimers for the study of multivalent carbohydrate–protein interactions

• Yoann M. Chabre,
• Alex Papadopoulos,
• Alexandre A. Arnold and
• René Roy

Beilstein J. Org. Chem. 2014, 10, 1524–1535, doi:10.3762/bjoc.10.157

• experimental conditions that often biased the intrinsic phenomena under investigations [29]. For instance, when evaluating thermodynamic parameters by isothermal calorimetry (ITC), scientists used either truncated versions of for instance, tetrameric lectins such as ConA, or diluted conditions to avoid

RAFT polymers for protein recognition

• Alan F. Tominey,
• Julia Liese,
• Sun Wei,
• Klaus Kowski,
• Thomas Schrader and
• Arno Kraft

Beilstein J. Org. Chem. 2010, 6, No. 66, doi:10.3762/bjoc.6.66

• : electrostatic interactions; hydrophobic effect; isothermal calorimetry; protein recognition; RAFT polymers; Introduction The ability of biological receptors to bind strongly and specifically to a particular molecular target is an essential part of biological machinery. The best example is the immune system

Preparation, structures and preliminary host–guest studies of fluorinated syn-bis-quinoxaline molecular tweezers

• Markus Etzkorn,
• Jacob C. Timmerman,
• Matthew D. Brooker,
• Xin Yu and
• Michael Gerken

Beilstein J. Org. Chem. 2010, 6, No. 39, doi:10.3762/bjoc.6.39

• units are matched appropriately. Further experiments employing complementary analytical techniques, e.g., isothermal calorimetry, as well as additional investigations of the host–guest chemistry with suitable, larger guest compounds, will provide detailed thermodynamic parameters of the host–guest